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His research led the Lasker Foundation to award him its prize in 1967. [125] More recently, in 2002, Alam, et al. , studied stool samples from patients at the International Centre for Diarrhoeal Disease in Dhaka, Bangladesh. cholerae through the human digestive system and an increased infectivity state. Furthermore, the researchers found the bacterium creates a hyperinfected state where genes that control biosynthesis of amino acids, iron uptake systems, and formation of periplasmic nitrate reductase complexes were induced just before defecation. These induced characteristics allow the cholera vibrios to survive in the ”rice water” stools, an environment of limited oxygen and iron, of patients with a cholera infection. [126] In 2017, the WHO launched the ”Ending Cholera: a global roadmap to 2030” strategy which aims to reduce cholera deaths by 90% by 2030. [127] The strategy was developed by the Global Task Force on Cholera Control (GTFCC) which develops country-specific plans and monitors progress.
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