The clinical care of PLHIV by health professionals, including nutritionists, demands identifying these disorders since they can contribute to poor adherence to dietary plans. Poor adherence increases the nutritional risk of these people. Therefore, studies searching for most the appropriate tools for screening HAND can contribute to the work of the multidisciplinary team. Objectives: This study aimed to identify different HAND screening tools, and their comparison with the ”gold standard” method”, the neuropsychological battery. Methods: This study consists of a systematic review (SR) registered in PROSPERO CRD42021227122. We included epidemiological or clinical studies with PLHIV adults, published from 2007 onwards, which have studied the validation of screening tools for HAND against a neuropsychological battery. Studies were searched in six databases (LILACS, PubMed, Embase, Web of Science, Scopus, and Scielo). Main Results: The search generated 1,505 articles; after applying the inclusion and exclusion criteria, 15 studies, mostly classified as having good methodological quality, took part in the RS.
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