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(1969) indicating 3 β -HSD/Δ 5 − 4 -isomerase activity in the chorion was also extended by Gant et al . (1977) . In addition, they observed low levels of steroid 5 α -reductase activity. More recently, Gibb et al . (1978) carried out an extensive comparison of 3 β -HSDs from human fetal membranes and placentas. The activities in chorion and placenta were very similar with respect to subcellular localization, specific activity, substrate specificity, nucleotide specificity, and steroid binding properties. This group of investigators has also shown that both chorion and amnion contain the aromatase complex ( Gibb and Lavoie, 1981 ). Thus, it is apparent that the fetal membranes have the full potential to synthesize estrogens and progesterone from DHEAS and P 5 S, a not surprising conclusion in view of the common trophoblastic origin of the placenta and chorion laeve. Bélgica sub 21.
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