A child with chickenpox. A child with chickenpox. Pregnancy and neonates Edit. Damage to brain: encephalitis, [26]microcephaly, hydrocephaly, [27]aplasia of brain Damage to the eye: optic stalk, optic cup, and lens vesicles, microphthalmia, cataracts, chorioretinitis, optic atrophy Other neurological disorder: damage to cervical and lumbosacral spinal cord, motor/sensory deficits, absent deep tendon reflexes, anisocoria/Horner's syndrome Damage to body: hypoplasia of upper/lower extremities, anal and bladder sphincter dysfunction Skin disorders: (cicatricial) skin lesions, hypopigmentation. Pathophysiology Edit. Exposure to VZV in a healthy child initiates the production of host immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) antibodies; IgG antibodies persist for life and confer immunity.
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