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Interestingly, activity was lower in week 10 than at term and three- to fourfold higher activity was observed with membranes from anencephalic fetuses. An early study by Jirásek et al . (1969) indicating 3 β -HSD/Δ 5 − 4 -isomerase activity in the chorion was also extended by Gant et al . (1977) . In addition, they observed low levels of steroid 5 α -reductase activity. More recently, Gibb et al . (1978) carried out an extensive comparison of 3 β -HSDs from human fetal membranes and placentas. The activities in chorion and placenta were very similar with respect to subcellular localization, specific activity, substrate specificity, nucleotide specificity, and steroid binding properties. This group of investigators has also shown that both chorion and amnion contain the aromatase complex ( Gibb and Lavoie, 1981 ). Thus, it is apparent that the fetal membranes have the full potential to synthesize estrogens and progesterone from DHEAS and P 5 S, a not surprising conclusion in view of the common trophoblastic origin of the placenta and chorion laeve. Amniotic fluid contains an abundant supply of steroidal sulfates that can serve as substrates for these biosynthetic enzymes, including DHEAS, 16-OH-DHEAS, pregnenolone, and 16 α -OH-P 5 S ( Schindler and Siiteri, 1968 ). Aposta futebol bet.In addition to those, there are so-called “double chance” bets.
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