3β-HSD is responsible for the conversion of pregnenolone to progesterone, 17β-hydroxypregnenolone to 17β-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to androstenedione and androstenediol to testosterone. 3β-HSD is encoded by two closely related genes located on chromosome 1 (1p13.1), HSD3B2 and HSD3B1, coding for type II and I isozymes, respectively. Type I isozyme (HSD3B1) is mainly expressed in the placenta and peripheral tissues, and type II isozyme (HSD3B2) is mainly expressed in the adrenal gland and gonads [4,5]. In addition to adrenal insufficiency, gonadal function is also impaired in patients with 3β-HSD2 deficiency. Affected male individuals encounter incomplete virilization, with clinical signs ranging from mild hypospadias to genital ambiguity due to impaired testosterone biosynthesis. 46XX individuals have normal female genitalia or show moderate signs of virilization of the external genitalia with clitoromegaly.
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Even against a player who very rarely folds to 3 bets, this can lead to higher value hands while cutting out some potential bluffs. Another reason 3 and 4 betting is growing in popularity is to squeeze the most value possible out of a hand. This is especially true of the strongest hands such as AA/KK/QQ which you are more likely going to play anyway. Reddit and its partners use cookies and similar technologies to provide you with a better experience. What Top Poker Pros Already Know About 4-Betting. Stick around until the end to grab your exclusive coupon code for $50 off Nick Petrangelo’s advanced tournament course, which expires in a few days. Why Do We 4-Bet? We obviously can’t only 4-bet premium hands. If we did that, our opponents would have an easy decision versus our 4-bets. 2.
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