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[ citation needed ] The condition was initially described by Dr. James Paget. In a paper published in 1877, Paget told of five patients with ”a rare disease of bones” which presented with slowly progressive bone deformities in the 4th and 5th decades of age. [38] Strikingly, the first patient was described to have many of the classic complications of the disease, including arthritis related to abnormal bone mechanics, cranial nerve palsies associated with an enlarging skull, and malignant transformation of a tumor of the radius which ultimately proved fatal. Paget's post-mortem autopsy evaluation showed ”bones of the vault of this skull were in every part increased to about four times the normal thickness,” and microscopic evaluation showed evidence of both bone erosion and abnormal remodeling. Although he incorrectly attributed the findings to a process of chronic inflammation, having ruled out tumor and hypertrophy as alternative etiologies, these prescient observations of a mixed destructive/regenerative process correspond to the modern understanding of the disease. No ar desde 2012, o Quinto Canal é um projeto que se orgulha de juntar nemean lion num só espaço o melhor da Televisão, Música, Cinema e Séries, a par das melhores rubricas e coberturas exclusivas. However, there are patients who have complaints from Paget's disease. These include: The prevalence of Paget's disease of bone has been decreasing in recent years. Casino 365.R$ 1.640,42 no Pix. Conjunto Box King 193cm com Molas Tower Gazin.
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The first clinical manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. [6] The goal of treatment is to relieve bone pain and prevent the progression of the disease. [8] These medications are usually recommended for people with Paget's disease who: [ citation needed ] A more recent meta-analysis determined that a causal link between calcitonin and cancer is both unlikely and antithetical to known biology, although a weak association was not definitively excluded. [31] The available studies for analysis were inconsistent and nonspecific, with one study [32] noting an increased risk of liver cancer and decreased risk of breast cancer. This was not replicated in any other study. [ citation needed ] Exercise is very important in maintaining skeletal health, avoiding weight gain, and maintaining joint mobility. Since undue stress on affected bones should be avoided, people with Paget's disease of bone should discuss any exercise program with their physicians or physical therapists before beginning. [ citation needed ] The condition was initially described by Dr. James Paget. In a paper published in 1877, Paget told of five patients with ”a rare disease of bones” which presented with slowly progressive bone deformities in the 4th and 5th decades of age. [38] Strikingly, the first patient was described to have many of the classic complications of the disease, including arthritis related to abnormal bone mechanics, cranial nerve palsies associated with an enlarging skull, and malignant transformation of a tumor of the radius which ultimately proved fatal. Paget's post-mortem autopsy evaluation showed ”bones of the vault of this skull were in every part increased to about four times the normal thickness,” and microscopic evaluation showed evidence of both bone erosion and abnormal remodeling.
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