Clinical trial data showed that the Ad5-nCoV vaccine had an efficacy of 58% against symptomatic disease and 92% against severe COVID-19. SAGE recommends the use of Ad5-nCoV vaccine as a single dose (0.5 ml) given intramuscularly into the deltoid muscle. In accordance with the WHO Prioritization Roadmap, a booster dose is recommended for the highest and high priority-use groups (i.e. older adults, health workers, persons with comorbidities), administered 4–6 months after completion of the primary series. The Ad5-nCoV booster dose following a primary series with the inactivated COVID-19 vaccine developed by Sinovac (CoronaVac) was associated with higher vaccine effectiveness compared to a homologous CoronaVac booster. Ad5-nCoV vaccine may be used as a booster dose following a completed primary series using any other EUL COVID-19 vaccine. Does it prevent infection and transmission? Does it work against new variants of SARS-CoV-2 virus? SAGE currently recommends using this vaccine, according to the WHO Prioritization Roadmap.
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