Bate-papo ao vivo com bb ou iphone um membro da equipe de suporte da 22Bet. Hsd3b1 catalyzes the second step of steroidogenesis and is required for the synthesis of all steroids including 11-KT (Hsu et al., 2009). In human testis specimens, HSD17B14 protein has shown immunoreactivity in most of the seminiferous epithelium as well as in peritubular areas harboring Leydig cells (Sivik et al., 2012). Transfection of HSD17B14 in human breast cancer cells significantly decreased the levels of estradiol (Jansson et al., 2006), and further studies have suggested a role for HSD17B14 in the local inactivation of steroid (Lukacik et al., 2007). Therefore, we hypothesized that the increased expression levels of hsd3b1 during the sex reversal of grouper may promote the synthesis of 11-KT, while the increased expression level of hsd17b14 may lead to the inactivation of estradiol in this study. Conclusion.
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In addition, exogenous androgens could artificially induce the sex reversal of groupers from female to male (Chen et al., 2011; Oh et al., 2013; Murata et al., 2014). However, little is known about the expression profiles of sex steroid synthesis and metabolism genes in the natural sex reversal process. HSDs participate in the synthesis and metabolism of sex steroid hormones by catalyzing the conversion of a hydroxy group to a keto group or vice versa on a steroid ring in a specific position and orientation (Yang et al., 2005). Studies on the expression profiles of hsd genes at different stages of grouper sex reversal may provide us a better understanding on the roles of hsd genes in sex reversal. In the gonad, two ( hsd3b1 and hsd17b14 ) and eight ( hsd3b7 , hsd17b1 , hsd17b7l , hsd17b10 , hsd17b12a , hsd17b12b , hsdl1 , and hsdl2 ) β -HSD genes were up- and downregulated during sex reversal, respectively. Hsd3b1 catalyzes the second step of steroidogenesis and is required for the synthesis of all steroids including 11-KT (Hsu et al., 2009). Aposta esportiva torcida.
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